Extended Data Fig. 3: Structural comparison of SMO and Gi protein in the different states.
From: Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling
a, Structural comparison of SMO–Gi–SAG complex with the previously reported structure of SMO–Gi–24(S),25-EC complex (PDB: 6OT0). b, structural comparison of SMO in SMO–Gi– SAG complex with inactive SMO (PDB: 5L7D). c, Structural comparison of 3.1-Å SMO–Gi–24(S),25-EC complex with the previously reported structure of SMO–Gi–24(S),25-EC complex (PDB: 6OT0). d, Structural comparison of Gi proteins in these reported four complexes.
