Extended Data Fig. 3: Cell free RTA and iron chelator profiling.
From: A compendium of kinetic modulatory profiles identifies ferroptosis regulators
a, Overview of cell free compound profiling for radical trapping and Fe2+-binding activity. b, Cell death at 48 h in HT-1080N cells treated with erastin2 (1 µM) and candidate radical trapping compounds (50 µM, n = 100) plotted against predicted hydrophilicity (LogS), predicted lipophilicity (LogP) and the %DPPH inhibition values from the cell-free assay. Dotted lines indicate a lethal fraction of 0.2. Spearman correlation values are reported with the 95% confidence interval (C.I.). Exact P values (two-tailed) are reported where computable.
