Extended Data Fig. 1: HER2 degradation by Ptz-GalNAc is inhibited by exogenous tri-GalNAc ligand.
From: LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation
Degradation of HER2 in HEPG2 cells determined by live-cell flow cytometry following co-treatment with DMSO or 5 mM of exogenous tri-GalNAc ligand (10) and 10 nM Ptz conjugates for 48 h. Data are the mean of three independent experiments ± SEM. P values were determined by unpaired two-tailed t-tests.
