Extended Data Fig. 2: Ptz-GalNAc internalizes membrane HER2 within 2 hours.
From: LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation
a, Visualization of HER2 in HEPG2 cells by confocal microscopy after 10 nM pertuzumab conjugate treatments for 2 h. EEA1 is included as an early endosomal marker. b, Visualization of HER2 in HEPG2 cells by confocal microscopy after 10 nM pertuzumab conjugate treatments for 48 h. EEA1 is included as an early endosomal marker. Images are representative of two independent experiments. Scale bar, 30 µm.
