Extended Data Fig. 3: Ctx-GalNAcs show similar lysosomal health as untreated cells.
From: LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation
a, Visualization and quantification of Lysotracker by confocal microscopy imaging of HEP3B cells treated with 10 nM cetuximab conjugates for 48 h or 1 mM LLOMe for 1 hour. b, Visualization and quantification of Cathepsin B activity using Magic Red in HEP3B cells treated with 10 nM cetuximab conjugates for 48 h or 1 mM LLOMe for 1 h. c, Visualization and quantification of ALIX in HEP3B cells treated with 10 nM cetuximab conjugates for 48 h or 1 mM LLOMe for 1 h. Scale bar, 30 µm. Values are the average ± SEM of three separate images from confocal microscopy. P values were determined by unpaired two-tailed t-tests.
