Extended Data Fig. 10: Structural comparison of MaTfuA and proteins with partial structural similarity.
From: Functional elucidation of TfuA in peptide backbone thioamidation
a, Overall structure of MaTfuA. b, Structure of myo-inositol-binding protein (PDB code: 4IRX) bound to its substrate (yellow stick) shows similarities with the α/β fold of MaTfuA (c) Structure of subtilisin BPN’ in complex with its prodomain (PDB code: 3CNQ) shows similarities with the α/β fold of MaTfuA. d, Close-up view of the superimposition between MaTfuA and 3CNQ shows the putative binding pocket for a peptide substrate. Residues that form the presumptive binding pocket are shown as tan (stick); the prodomain bound by subtilisin BPN’ is shown in blue (stick).
