Extended Data Fig. 2: The tryptophan-rich signature motif (WXWD).
From: Architecture of the membrane-bound cytochrome c heme lyase CcmF
In all classes of heme lyases, a tryptophan-rich motif is suggested to be directly involved in the handling of the heme cofactor. It is found in human cytochrome c synthase (HCCS), as well as in the lyase CcsA of system II and the components CcmC and CcmF of system I.
