Extended Data Fig. 1: Model and electron density quality of the HUWE1N crystal structure.
From: HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain
a, The anomalous difference Fourier map at 2.5 σ is shown over representative ARM repeats from the structure of SeMet HUWE1N. Selenomethionines are colored in cyan. b, The asymmetric unit is shown with the two copies of HUWE1N colored in green and cyan, in cartoon representation. The 2FO-FC map at 1 σ is displayed. c, Representative 2FO-FC map at 1 σ of the ARM repeats.
