Extended Data Fig. 2: Details of the HUWE1N solenoid and comparison with human HUWE1.
From: HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain
a, The primary and tertiary structure of HUWE1N is shown as in Fig. 2a, but with every ARM repeat labelled. b, The predicted positions of the previously annotated human HUWE1 domains in the context of the HUWE1N structure. The D/E-rich region is highly conserved in character and corresponds to HUWE1N IDR1. c, The predicted positions of X-linked intellectual disability mutations on the structure of HUWE1N. Mutated residues are shown in sphere representation, with HECT domain mutations in orange and all other mutations in blue.
