Extended Data Fig. 5: Comparison of SP-NK1R binding site to related Neuropeptide GPCRs and Inactive-State NK1R Structures.
From: Selective G protein signaling driven by substance P–neurokinin receptor dynamics
Comparison of SP-bound NK1R-miniGs/q70 structure to neuropeptide GPCRs bound to peptidergic ligands, including: (a) the neurotensin 1 receptor bound to neurotensin 8-13 (PDB: 6OS922), (b) the μ-opioid receptor bound to the peptide mimetic agonist DAMGO (PDB: 6DDE26), and (c) the orexin 2 receptor bound to orexin B (PDB: 7L1U27). Alignment of SP-bound NK1R with inactive-state NK1R structures, including: (d) netupitant-bound (PDB: 6HLP24), (e) aprepitant-bound (PDB: 6HLO24), (f) L-760,735-bound (PDB: 6E5928), and (g) CP-99,994-bound NK1R (PDB: 6HLL24). (h) Antagonist chemical structures shown with regions that compete with SP binding site in red.
