Extended Data Fig. 9: Comparison of NK1R G protein-complexes.
From: Selective G protein signaling driven by substance P–neurokinin receptor dynamics
Alignment of SP-NK1R-miniGs/q70 and SP6-11-NK1R-miniGs/q70 through NK1R 7TM domain reveals minimal changes in (a) overall 7TM architecture, (b) overall peptide binding poses, and (c) insertion of miniG protein α5 helix in NK1R core. Alignment of SP-NK1R-miniGs/q70 and SP-NK1R-miniGs399 through NK1R 7TM domain reveals minimal changes in (d) overall 7TM architecture, (e) overall SP binding pose, and (f) insertion of miniG protein α5 helix in NK1R core.
