Extended Data Fig. 8: The adenine riboswitch core is smaller than that of Squash.
From: The fluorescent aptamer Squash extensively repurposes the adenine riboswitch fold
a, Ball-and-stick representations of each of the five tiers (numbered 1-5 in bold numerals) that comprise the adenine riboswitch core (PDB ID:1Y26; ref. 3). Orange dashed lines denote hydrogen bonds. Base pairs in the secondary structure are in Leontis-Westhof symbols4. Compare with Supplementary Fig. 3. b, Structure-based sequence alignment of Squash (sq) and the V. vulnificus add adenine riboswitch aptamer domain (ar). Residue numbers correspond to Squash. Color scheme is that of Fig. 1. Asterisks and periods denote sequence identity and gaps needed to account for Squash being longer, respectively. Junction regions J1/2, J2/3 and J3/1 have no clear structural correspondence and the residues in these regions are not aligned.
