Extended Data Fig. 4: Quality assessment of model-to-map fitting for the NorA-Fab complexes.
From: Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus
a, b. The quality of the NorA-Fab25 (a) and NorA-Fab36 (b) models are illustrated by their respective fit into the experimental maps (shown in mesh). The model-to-map fitting is shown for each TM helix in NorA and a portion of the CDRH3 loop from each Fab. The map contour level was set to 10 sigma units for each TM helix and CDRH3 loop using the isomesh command in PyMOL. The following residues comprise each TM domain: TM1, 2-26; TM2, 37-63; TM3, 69-87; TM4, 91-115; TM5, 125-148; TM6, 155-175; TM7, 203-228; TM8, 238-264; TM9, 270-287; TM10, 297-320; TM11, 325-351; TM12, 356-374.
