Extended Data Fig. 6: Synergy calculations for co-inhibition experiments where inhibition of the co-target showed significant concentration-dependent toxicity. | Nature Chemical Biology

Extended Data Fig. 6: Synergy calculations for co-inhibition experiments where inhibition of the co-target showed significant concentration-dependent toxicity.

From: Systematic identification of biomarker-driven drug combinations to overcome resistance

Extended Data Fig. 6: Synergy calculations for co-inhibition experiments where inhibition of the co-target showed significant concentration-dependent toxicity.The alt text for this image may have been generated using AI.

(a) Legend for (b–d) where combination effect (deviation from null model) is shown by color. (b–d) Deviation from Loewe additivity (synergy) for the combinations (b) navitoclax x S63845, (c) doxorubicin x WEHI-539, and (d) PRIMA-1 x erastin across a panel of cell lines. The overall F-statistic and two-sided P-value (from meanR test) are shown for each cell line.

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