Extended Data Fig. 3: Representative structural homologs of the PRP and gPRT domains.
From: The biosynthetic origin of ribofuranose in bacterial polysaccharides
All structures were superimposed on ORF4Tc. Models are colored using rainbow (N-terminus dark blue, C-terminus red). a, PRP domain of ORF4Tc. b, Protein of unknown function from Pyrococcus horikoshii (1 × 42). c, PRP domain of human soluble epoxide hydrolase (5aln). d, Pseudomonas syringae haloacid dehalogenase (3vay). e, Human enolase phosphatase 1 (1yns). f, Human chronophin (2oyc), a bifunctional pyridoxal phosphate and cofilin phosphatase (note that this HAD lacks a helical cap domain, and has a second Rossmann domain fused instead). g, The gPRT domain of ORF4Tc h, Giardia lamlia guanine phosphoribosyltransferase (1dqn) i, Shewanella pealeana hypoxanthine phosphoribosyltransferase (4lyy). j, Toxoplasma gondii hypoxanthine-guaninephosphoribosyltransferase (1fsg).
