Extended Data Fig. 7: No correlation between IR-Alus induced dsRNA and basal IFN signature.
From: PRMT inhibition induces a viral mimicry response in triple-negative breast cancer
a. Quantification of cytoplasmic dsRNA signal intensity across four TNBC cell lines (means±s.d., n = 3 independent biologically experiments of at least 85 cells per group analyzed). b. Distribution of dPSI for classes of alternative splicing events that correlates with MS023 sensitivity. Each dot represents a potential splicing event from n = 3 biological independent experiments. In the boxplots, the centre lines mark the median, the box limits indicate the 25th and 75th percentiles, and the whiskers extend to 1.5× the interquartile range from the 25th and 75th percentiles (unpaired two-tailed Student’s t-test).
