Extended Data Fig. 4: Structural comparison of an active and inactive state of CB1.

Comparison of agonist bound CB1 (PDB: 6KPG) with antagonist bound CB1 structures (PDB: 5TGZ), including C^6.47W^6.48xP^6.50, P^5.50-I^3.40-F^6.44 (L286^5.50-V204^3.40-L352^6.44), N^7.49P^7.50xxY^7.53, D^3.49R^3.50Y^3.51 motifs.