Extended Data Fig. 5: Structural comparison of the MRGPRX1-Gq-BAM8-22 complex with MRGPRX1-Gq-BAM8-22/ML382 complex.
From: Ligand recognition and allosteric modulation of the human MRGPRX1 receptor
a-c, The overall alignment of the MRGPRX1-Gq-BAM8-22 complex with MRGPRX1-Gq-BAM8-22/ML382 complex. Side-view to show the overall complexes (a). Extracellular view to show the overall similar peptide binding mode (b). Intracellular view to show the α5 binding pocket (c). d, Cross-section image to show the binding of BAM8-22 and ML382 in MRGPRX1. e, Cross-section image to show the binding of BAM8-22 alone in MRGPRX1.
