Extended Data Fig. 7: Structural comparison of MRGPRX1-Gq-compound-16 complex with MRGPRX1-Gq-BAM8-22/ML382 complex.
From: Ligand recognition and allosteric modulation of the human MRGPRX1 receptor
a, The orthosteric pocket for compound-16 (cyan) is larger than that of BAM8-22 (green). b-c, Structural superposition of MRGPRX1-Gq-compound-16 complex and MRGPRX1-Gq-BAM8-22/ML382 to show compound-16 has a weak contact with the allosteric modulator ML382. Side view (b). Top view (c). d, ML382 displays very weak PAM activity at compound-16 in BRET2 Gq activation assay. Data are mean ± SEM of n = 4 biological replicates.
