Extended Data Fig. 3: Comparison of MRGPRX1 PAM binding site with other GPCRs.
From: Ligand recognition and allosteric modulation of the human MRGPRX1 receptor
a-d, The binding modes of agonist and PAM of MRGPRX1 (a), M2R (PDB ID: 4MQT) (b), GPR40 (PDB ID: 5TZY) (c) and DRD1 (PDB ID: 7LJD) (d). The peptide agonist is shown as cartoon. Small molecule orthosteric agonists and PAMs are shown as sticks. Orthosteric agonist and PAM are colored by bule and yellow, respectively.
