Extended Data Fig. 4: Mutations of MRGPRX1 allosteric site residues affect ML382 allosteric properties.
From: Ligand recognition and allosteric modulation of the human MRGPRX1 receptor
a-l, Representative Gq BRET2 dose–response curves of WT and mutations of key residues of MRGPRX1 in the presence of indicated concentration of the allosteric modulator ML382. Data are mean ± SEM of n = 3 biological replicates.
