Extended Data Fig. 5: VbP sensitizes the CARD8 inflammasome to HIV-1.
From: Chemical inhibition of DPP9 sensitizes the CARD8 inflammasome in HIV-1-infected cells
a, VbP overcomes reduced RPV killing efficacy by human serum. Dose response curves for killing of HIV-1-infected CD4+ T cells treated with RPV or combo (VbP 1 µM) with or without the presence of 50% human serum. Zero values of RPV were plotted at 0.1 nM to allow for log transformation. Error bars show mean values with SEM (n = 3). b–e, Time course treatment of three donors of HIV-1 infected primary CD4+ T cells (b, c) or THP-1 cells (d, e). Cells were treated with DMSO, EFV (0.5 µM), VbP (1 µM), or combo. Fold change enhancement of combination treatment in comparison to EFV alone treatment was shown in (c) and (e).
