Extended Data Fig. 6: Depleted cluster and Hoechst- sensitivity cluster in the structural context of outward- facing EfrCD. | Nature Chemical Biology

Extended Data Fig. 6: Depleted cluster and Hoechst- sensitivity cluster in the structural context of outward- facing EfrCD.

From: Deep mutational scan of a drug efflux pump reveals its structure–function landscape

Extended Data Fig. 6

Side-by-side representation of inward-facing EfrCD structure (a and d) and outward-facing EfrCD homology model (b, c, e and f) based on the coordinates of Sav1866 (PDB: 2HYD). The depleted cluster residues are colored in blue (a-c) and the Hoechst-sensitivity cluster residues in purple (d-f).

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