Extended Data Fig. 3: Variant filtering.
From: Deep mutational scan of a drug efflux pump reveals its structure–function landscape
a, Variant scores determined in the absence of drugs (see Extended Data Fig. 2) were ordered according to the score value. Annotated variants colored in blue deviate strongly from wild-type EfrCD (variant score = 0) and were excluded in the DMS analysis (gray squares in Fig. 3). b, c, d, Standard errors calculated by Enrich2 for all variants ordered according to their value for daunorubicin (b), Hoechst (c) and ethidium (d). Variants exhibiting suspiciously high standard errors are colored in blue and annotated. These variant scores were excluded in the DMS analysis (gray squares in Fig. 3).
