Extended Data Fig. 2: Structure of EXT1-2.
From: Structural basis for heparan sulfate co-polymerase action by the EXT1–2 complex
a, Superimposition of GT-B fold of EXT1 and EXT2. The intervening loop in red dash cycle. b, Superimposition of GT-A fold from EXT1, EXT2, and mEXTL2 (PDB ID: 1ON6). c, Top view of GT-B fold in EXT1-2, suggesting a pseudo-twofold symmetry. d, Superimposition of GT-A fold from EXT1-2 and mEXTL2 (PDB ID: 1ON6) in top view, suggesting a pseudo-twofold symmetry for GT-A fold in EXT1-2. EXT1-2 is colored the same as Fig. 1, and mEXTL2 in cyan.
