Extended Data Fig. 10: Prediction of metal-binding sites in the human spliceosome.
From: Co-evolution-based prediction of metal-binding sites in proteomes by machine learning
a, Scheme of predicting metal-binding sites in the human spliceosome using coevolution obtained by deepMSA and MSA transformer. b, Highlight of the zinc-binding sites in the human spliceosome predicted by MetalNet that match well with the experimental structures in PDB. The experimental structures of the corresponding metalloproteins subunits are shown in cartoon on the left and the predicted coevolution networks corresponding to the metal-binding sites are shown on the right. Metal-chelating residues are shown in sticks and zinc ions are shown in spheres.
