Fig. 1: ME7 fibril morphologies and the atomic structure of their constituent PrP subunit. | Nature Chemical Biology

Fig. 1: ME7 fibril morphologies and the atomic structure of their constituent PrP subunit.

From: A structural basis for prion strain diversity

Fig. 1

a, Representative cryo-EM image from a dataset comprising 6,370 multi-frame movies (300-kV FEI Krios G3i, K3 camera) showing examples of single ME7 protofilaments (s) alongside their paired assemblies (p) with their approximate diameters. b, Protein-only density of a single amyloid rung (pink) with the fitted atomic model of the mouse PrP chain shown with sticks colored by heteroatom: C, white; N, blue; O, red; S, yellow. The start (T94) and end (R229) residues of the fitted polypeptide and both N-glycosylation sites are indicated.

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