A crucial step in the cell-death process of ferroptosis is the incorporation of free polyunsaturated fatty acids (PUFAs) into membrane phospholipids. An enzyme has now been identified that contributes to ferroptosis by directly transferring PUFAs from phospholipids to ether lysophospholipids to form ether phospholipids.
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An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis
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Lee, JY., Kim, J.W. & Lee, EW. A new way to create ether lipids. Nat Chem Biol 19, 259–260 (2023). https://doi.org/10.1038/s41589-023-01255-z
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DOI: https://doi.org/10.1038/s41589-023-01255-z
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An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis
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