Extended Data Fig. 5: Substrate 13 is more toxic than 6 in vivo.
From: An optimized bioluminescent substrate for non-invasive imaging in the brain
For kidney: asterisks, renal tubular dilation; arrows, renal tubular degeneration and luminal sloughing. For heart: asterisks, myocardial necrosis and hemorrhage. No lesions were noted in the lungs across any groups. The selected images were representative dissection images with the most severe damage of three biological replicates for illustration purposes. Scale bars, 50 μm in kidney, liver, and lung, and 500 μm in heart. Detailed scores of histology analysis of all biological replicates are summarized in Supplementary Table 1.
