Extended Data Fig. 7: Spatial profiles of AI-2-QS-related genes in biofilm.
From: Spatial transcriptome uncovers rich coordination of metabolism in E. coli K12 biofilm
Spatial profiles of AI-2-QS-related genes in biofilm. (a) AI-2-mediated QS in E. coli. (b) The log2(fold change) between biofilm periphery (n = 5) and exponential phase of planktonic culture (n = 2) are presented as heatmaps for AI-2 related genes. The spatial profile (n = 5; solid line and shaded area indicate mean ± std) of AI-2 (c) biosynthesis, (d) import and (e) processing in biofilm. (f) Utilization of secondary metabolites at intermediate region within biofilm. Shown is log2(fold change) relative to average of each profile; abbreviations: GABA, gamma-aminobutyric acid. See ‘Signaling mediated by AI-2 QS and c-di-GMP in biofilms uncovered by RAINBOW-seq’ subsection in Methods for more discussions about AI-2 quorum sensing in biofilm learned from RAINBOW-seq data.
