Extended Data Fig. 6: Characterizing the effects of cisplatin and doxorubicin.
From: Cytosolic and mitochondrial NADPH fluxes are independently regulated
a, Dose-response analysis for cisplatin administered to HCT116 wild-type cells. Cell proliferation was assessed at increasing concentrations of drug. b, Dose-response analysis for doxorubicin administered to HCT116 wild-type cells. Cell proliferation was assessed at increasing concentrations of drug. c, Percent decreased viability of cells treated with 10 μM cisplatin for 48 hours. Data were obtained by using an MTT assay. Values are mean ± s.d; n = 8 biologically independent samples (a-c, n = 7 biologically independent samples for WT in c). Statistically significant differences were calculated by using a one-way ANOVA followed by Dunnett’s multiple comparison test (c). NS= no significant difference.
