Fig. 6: Association of thermal proteoform stability to drug sensitivity across cALL cell lines.
From: Deep thermal profiling for detection of functional proteoform groups
a, Schematic of the strategy to test for thermal proteoform stability drug sensitivity associations. Linear models were built using limma to test for correlation between thermal stability and drug response; obtained P values were adjusted for multiple testing using the Benjamini–Hochberg method. AUC, area under the curve. b, Volcano plot representing the results obtained from the limma linear modeling workflow depicted in a. c,d, Scatter plot of CRKL_1 and EPS8L2_2 thermal stability and cell line drug sensitivity to imatinib and eltanexor, respectively. The Pearson correlation coefficient (⍴) is shown in each scatter plot. The linear regression trendline (black) and its 95% confidence interval (shaded gray area) are shown in the scatter plots.
