Extended Data Fig. 3: Variations of cell growth rate and stability of mutual repressive circuit under the treatment of diverse concentrations of sublethal dose of mupirocin.
From: Unbalanced response to growth variations reshapes the cell fate decision landscape
Mupirocin is a translation inhibitor that inhibits the charging of isoleucine tRNA, resulting in a reduction of the translational elongation rate of the ribosome. E coli. cells harboring the mutual repressive circuit were grown in MOPS glucose minimal medium with diverse concentrations of mupirocin varying from 0 to 60 µg/mL. A loss of bistability was observed under slow growth when varying the cell growth rate by titrating the translational elongation rate.
