Extended Data Fig. 8: Misincorporation probability (Fpol) of dA•dGTP and dA•8OGTP from kinetic simulations.
From: Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs
Shown are the Fpol calculated from the simulated Kd and kpol for the reference Watson-Crick dA•dTTP bp and dA•dGTP or dA•8OGTP. Data presented for the reference experimental (Exp) values as solid bar graphs were obtained from their corresponding reference for A•G37 (left), its pH dependence39 (middle) and the impact of 8OG40 (right). Data presented for the computational kinetic modeling as the white bar graphs are presented as mean values ± 1 s.d. (not visible) from Monte Carlo simulations (number of iterations = 200) as described in Methods.
