Extended Data Fig. 10: Signaling of RXFP1 constructs by the small molecule agonist ML290.
From: The relaxin receptor RXFP1 signals through a mechanism of autoinhibition
a, Gs signaling at wild type RXFP1 and ECL2 mutants at basal levels and in response to 490 nM ML290. Data is mean ± s.e.m., n = 3 technical replicates. b, Gs signaling at constructs of the RXFP1 7TM domain fused to the β2 adrenergic receptor N-terminus at basal levels and in response to 490 nM ML290. Data is mean ± s.e.m., n = 3 technical replicates.
