Extended Data Fig. 4: Alignments of RXFP1’s ECL2 with GPR52 and family A orthosteric agonists. | Nature Chemical Biology

Extended Data Fig. 4: Alignments of RXFP1’s ECL2 with GPR52 and family A orthosteric agonists.

From: The relaxin receptor RXFP1 signals through a mechanism of autoinhibition

Extended Data Fig. 4: Alignments of RXFP1’s ECL2 with GPR52 and family A orthosteric agonists.The alternative text for this image may have been generated using AI.

Alignment of active-state RXFP1 (green, with ECL2 in magenta) (a), the β2 adrenergic receptor (gray) bound to adrenaline (purple; PDB ID: 4LDO)16 (b), and the angiotensin II type I receptor (gray) bound to the angiotensin II analog S1I8 (purple; PDB ID: 6DO1)17 (c), with GPR52 (gray with ECL2 in purple; PDB ID: 6LI3)18.

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