Extended Data Fig. 8: Comparison of 70S–MAAAPQKC–TcmX with earlier structures of the ribosome in complex with TcmX or other antibiotics. | Nature Chemical Biology

Extended Data Fig. 8: Comparison of 70S–MAAAPQKC–TcmX with earlier structures of the ribosome in complex with TcmX or other antibiotics.

From: Tetracenomycin X sequesters peptidyl-tRNA during translation of QK motifs

Extended Data Fig. 8

a,b, Structural comparison of the peptidyl transferase center and TcmX binding site in 70S–MAAAPQKC–TcmX (white) and in complexes between E. coli 70S (gray, PBD 6Y69) or human 80 S (pale green, PDB 6Y6X) ribosomes and TcmX (Ref. 6). c, d, Displacement of the 3’ end of peptidyl-tRNA (dark blue) by TcmX (c) or Blasticidin S (PDB 6B4V, Ref. 23). e, f, Displacement of the 3’ end of aminoacyl-tRNA (light blue) by (e) Hygromycin A (PDB 5DOY, Ref. 25) or (f) A201A (PDB 4Z3S, Ref. 25).

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