Extended Data Fig. 10: Possible way forward for the design of TcmX derivatives with increased specificity for the bacterial ribosome. | Nature Chemical Biology

Extended Data Fig. 10: Possible way forward for the design of TcmX derivatives with increased specificity for the bacterial ribosome.

From: Tetracenomycin X sequesters peptidyl-tRNA during translation of QK motifs

Extended Data Fig. 10

a, The O-methyl group attached to the D ring of TcmX could be used as a starting point to ‘grow’ the drug molecule towards a cavity lined with the backbone phosphate groups of 23S rRNA residues G2582 and G2608 in the E. coli ribosome (white). b, TcmX derivatives with suitable side chains attached to this position may retain activity against the bacterial ribosome while no longer binding to the human ribosome (pale green, PDB 6Y6X), where this cavity is blocked by 28S rRNA residue U1591.

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