Extended Data Fig. 5: Cis-Phe329 in FUT9.
From: Structural basis for Lewis antigen synthesis by the α1,3-fucosyltransferase FUT9
Residue Phe329 which precedes helix α12 is involved in a cis-bond (ω angle of ∼13°). Stabilizing interactions for the unfavorable bond angle include aromatic and aromatic edge−to-face stacking of Phe329 and Trp330. The cis-Phe is not observed in HpFucT due to the lack of structural conservation in the region.
