Extended Data Fig. 10: Interactions between PiB and the N-pocket of α-syn fibril.
From: Structural mechanism for specific binding of chemical compounds to amyloid fibrils
a, Interactions of two alternative conformations of PiB (colored in yellow and pink, respectively) with Y39 (colored in wheat) and V82 (colored in light purple) of α-syn. Three layers of α-syn molecules (i, i + 1, i + 2) are shown. Detailed interaction distances are labeled. b, Summary of the molecular interactions between PiB (conformation 1, left; conformation 2, right) and α-syn fibril (black). Interactions are depicted as blue dashed lines. c, π-π stacking of PiB conformations along the fibril axis. Detailed distances and angles are labeled.
