Extended Data Fig. 6: 3D particle subclassification of active, Gs-coupled AMY3R bound to San385, and map refinement for Cluster 5. | Nature Chemical Biology

Extended Data Fig. 6: 3D particle subclassification of active, Gs-coupled AMY3R bound to San385, and map refinement for Cluster 5.

From: Structural insight into selectivity of amylin and calcitonin receptor agonists

Extended Data Fig. 6: 3D particle subclassification of active, Gs-coupled AMY3R bound to San385, and map refinement for Cluster 5.

Top left, histogram of 10 particle clusters following masked 3D classification in Cryosparc. Clusters 4 and 5 (dashed red rectangle) exhibit a different conformation to the consensus map. Top right, receptor focused mask used in the 3D classification. Bottom, FSC curves and local resolution-filtered EM maps (receptor focused, left; consensus, right) derived from cluster 5.

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