Extended Data Fig. 7: The dynamic conformations of rAmy-CTR is likely correlated with lower stability of ECL3 arising from differences in the rotamer of W3616.58.
From: Structural insight into selectivity of amylin and calcitonin receptor agonists
Map to model representation of the mid-region of rAmy bound to CTR in CT-like conformation (A) or bypass motif conformation (B); amino acids of the mid-region are shown in stick representation. Model comparison of TMD bundles for San45-CTR and rAmy-CTR (CT-like conformation) complexes (C) and San45-AMY3R and rAmy-CTR (bypass conformation) (D) highlighting the distinct rotamer position of W3616.58 (stick representation).
