Extended Data Fig. 8: eIF2B δL516A mutation widens eIF2α binding pocket more than eIF2αP binding.

Overlay of atomic models of eIF2B-eIF2 (blue, PDB 6o81), eIF2B-eIF2αP (light peach, PDB 6o9z), and eIF2B δL516A (orange, PDB 8TQZ) showing widening of eIF2α binding pocket by \(2.1{\text{\AA }}\) for eIF2B-eIF2αP and 4.5 Å for eIF2B δL516A.