Extended Data Fig. 9: The typical assemblies of TIR domains.
From: Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system
a. The structure of TIR domain in SPARTA. The secondary structures are indicated. Eukaryotic TIR domains are primarily arranged either as ‘scaffold assembly’ (b) or ‘enzymatic assembly’ (c), corresponding to parallel or anti-parallel two-stranded assembly via distinct interfaces, respectively. The involved interfaces are indicated by the frames.
