Fig. 3: Synthesis of library of 8,448 cyclic peptides and screen against thrombin.
From: De novo development of small cyclic peptides that are orally bioavailable
a, Structures of amino acids, bis-electrophilic cyclization linkers and carboxylic acids used to synthesize the library. b, MW, PSA, number of HBDs, cLogP, number of HBAs and nRotBs of the cyclic peptides in the library. Peptides outside the rule-of-five (Ro5) space defined by Lipinski et al.32 are shown in gray. Asterisk indicates the physicochemical properties defined by Veber et al.42. c, Chemical structures and activities of purified cyclic peptides of group 1 indicated in Extended Data Fig. 2. The common core of the structure is colored in black. Mean and s.d. values of three independent measurements are shown.
