Extended Data Fig. 3: Thrombin inhibitor sub-library screen.
From: De novo development of small cyclic peptides that are orally bioavailable
Combined screening for permeability (PAMPA, 14 h, 5 μM) and thrombin inhibition. The heat maps show thrombin inhibition in donor (upper) and acceptor wells (lower). The screen was carried out at a theoretical equilibrium concentration of 1 μM.
