Extended Data Fig. 6: Docking of NBSI571 into the DFHBI or DFHO binding pocket of other fluorogenic RNA aptamer.
From: Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift
(a) Chemical structure of DFHBI, DFHO and NBSI571. (b) Docking of NBSI571 into the binding pocket of Spinach fluorogenic aptamer bound with DFHBI (PDB: 4TS0). (c) Docking of NBSI571 into the binding pocket of iSpinach fluorogenic aptamer bound with DFHBI (PDB: 5OB3) results in steric clash between the phenyl moiety of NBSI571, and the phosphate of G46 and the base of A50 from iSpinach. (d) Docking of NBSI571 into the binding pocket of Corn fluorogenic aptamer bound with DFHO (PDB: 5BJP). (e) Docking of NBSI571 into the binding pocket of Beetroot fluorogenic aptamer bound with DFHO (PDB: 8EYV) results in steric clash between the phenyl moiety of NBSI571, and the sugars of A34 and A37 from Beetroot.
