Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Synthetic biology

Orthogonal redox control

Nature Chemical Biology volume 20, pages 1395–1396 (2024)Cite this article

Subjects

The integration of a new orthogonal redox cofactor opens opportunities for controlling reaction equilibria. Because it does not interfere with cellular redox homeostasis, this approach enables the precise tuning of metabolic pathways and the optimization of microbial bioproduction, independently of canonical redox balancing.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The toolbox for use of the orthogonal redox factor NMN/H has been completed by combining in silico design and in vivo growth-coupled selection.
The alternative text for this image may have been generated using AI.

References

  1. Wang, M., Chen, B., Fang, Y. & Tan, T. Biotechnol. Adv. 35, 1032–1039 (2017).

    Article  CAS  PubMed  Google Scholar 

  2. Weusthuis, R. A., Folch, P. L., Pozo-Rodríguez, A. & Paul, C. E. iScience 23, 101471 (2020).

    Article  CAS  PubMed  Google Scholar 

  3. Aspacio, D. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-024-01702-5 (2024).

    Article  PubMed  Google Scholar 

  4. Black, W. B., Perea, S. & Li, H. Curr. Opin. Biotechnol. 84, 103019 (2023).

    Article  CAS  PubMed  Google Scholar 

  5. Black, W. B. et al. Microb. Cell Factories 19, 150 (2020).

    Article  CAS  Google Scholar 

  6. Black, W. B. et al. Nat. Chem. Biol. 16, 87–94 (2020).

    Article  CAS  PubMed  Google Scholar 

  7. Orsi, E., Schada von Borzyskowski, L., Noack, S., Nikel, P. I. & Lindner, S. N. Nat. Commun. 15, 1–14 (2024).

    Article  CAS  Google Scholar 

  8. Nielsen, J. R., Weusthuis, R. A. & Huang, W. E. Biotechnol. Adv. 63, 108102 (2023).

    Article  CAS  PubMed  Google Scholar 

  9. von Kamp, A. & Klamt, S. Nat. Commun. 8, 15956 (2017).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany

    Lena M. Hümmler & Steffen N. Lindner

Authors
  1. Lena M. Hümmler
    View author publications

    Search author on:PubMed Google Scholar

  2. Steffen N. Lindner
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Steffen N. Lindner.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hümmler, L.M., Lindner, S.N. Orthogonal redox control. Nat Chem Biol 20, 1395–1396 (2024). https://doi.org/10.1038/s41589-024-01728-9

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41589-024-01728-9

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research