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Glycobiology

Cracking the diversity of sweet drugs

Nature Chemical Biology volume 20, pages 1397–1398 (2024)Cite this article

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Characterization of the heterogeneity in the glycosylation of biotherapeutics is crucial for drug development but challenging. Now, an approach allows the rapid analysis of the glycosylation of intact glycoproteins, without prior processing or separation, enabling the study of glycan composition and quality assessment of any glycoprotein drug.

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Fig. 1: Intact mass spectrometry characterization approach for rapid profiling of biotherapeutics.

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Authors and Affiliations

  1. Department of Cell Research and Immunology, The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

    Sharon Yehuda & Vered Padler-Karavani

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  1. Sharon Yehuda
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  2. Vered Padler-Karavani
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Correspondence to Vered Padler-Karavani.

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The authors declare no competing interests.

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Yehuda, S., Padler-Karavani, V. Cracking the diversity of sweet drugs. Nat Chem Biol 20, 1397–1398 (2024). https://doi.org/10.1038/s41589-024-01755-6

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