Extended Data Fig. 3: Translation regulation activity of covalent preQ1 ligands.
From: Engineering covalent small molecule–RNA complexes in living cells
E. coli bacteria transformed with reporter constructs expressing GFP under the control of either the Tt WT preQ1 riboswitch or the C15U mutant riboswitch were tested for GFP fluorescence after 6 h of growth in the presence of the indicated ligands. Translational inhibition is expressed relative to the mock (water) control after correction for cell number and background fluorescence. Mean ± SD of three independent experiments with three technical replicates each is shown.
